Compare the2025 Audi S5 SportbackVS 2025 Mercedes AMG E-Class Sedan

Both the S5 Sportback and AMG E-Class Sedan have child safety locks to prevent children from opening the rear doors. The S5 Sportback has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The AMG E-Class Sedan’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.

The Audi S5 Sportback has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags helps prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The AMG E-Class Sedan doesn’t offer a front passenger side knee airbag.

The S5 Sportback has a standard Secondary Collision Brake Assist, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The AMG E-Class Sedan doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.

When descending a steep, off-road slope, the S5 Sportback’s standard Hill Descent Control allows you to creep down safely. The AMG E-Class Sedan doesn’t offer Hill Descent Control.

The S5 Sportback’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane and gently nudges the vehicle back towards its lane. A lane departure warning system costs extra on the AMG E-Class Sedan.

Both the S5 Sportback and the AMG E-Class Sedan have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, rearview cameras, available blind spot warning systems, around view monitors and rear cross-path warning.

The S5 Sportback’s corrosion warranty is 7 years longer than the AMG E-Class Sedan’s (12 vs. 5 years).

From surveys of all its subscribers, Consumer Reports’ January 2024 Auto Issue reports that Audi vehicles are more reliable than Mercedes vehicles. Consumer Reports ranks Audi 10 places higher in reliability than Mercedes.

To lower fuel costs and make buying fuel easier, the Audi S5 Sportback uses regular unleaded gasoline (premium recommended for maximum performance). The AMG E-Class Sedan requires premium, which can cost on average about 84.9 cents more per gallon.

The S5 Sportback’s standard tires provide better handling because they have a lower 35 series profile (height to width ratio) that provides a stiffer sidewall than the AMG E-Class Sedan’s standard 40 series front tires. The S5 Sportback’s optional tires have a lower 30 series profile than the AMG E-Class Sedan’s optional 35 series front tires.

The S5 Sportback has a standard space-saver spare tire so you can replace a flat tire and drive to have the flat repaired or replaced. A spare tire isn’t available on the AMG E-Class Sedan; it requires you to depend on roadside assistance and your vehicle will have to be towed.

The Audi S5 Sportback may be more efficient, handle and accelerate better because it weighs about 300 pounds less than the Mercedes AMG E-Class Sedan.

The S5 Sportback is 7.3 inches shorter than the AMG E-Class Sedan, making the S5 Sportback easier to handle, maneuver and park in tight spaces.

Laser headlights, standard on the S5 Sportback Prestige, produce their light by firing blue lasers through phosphorus, a process that uses one-half the power of the AMG E-Class Sedan’s LED headlights. Laser headlights can have double the range of LEDs with a much smaller surface area.

The Audi S5 comes in coupe, convertible and four door hatchback bodystyles; the Mercedes AMG E-Class isn’t available as a coupe or convertible.

The Audi A5/S5/RS 5 outsold the Mercedes E-Class/CLS by 39% during 2023.