Both the S3 and IS have child safety locks to prevent children from opening the rear doors. The S3 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The IS’ child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the S3. But it costs extra on the IS.
To help make backing out of a parking space safer, the S3 has standard Rear Cross-Traffic Assist with Automatic Brake Activation, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Rear Cross-Traffic Braking costs extra on the IS.
Both the S3 and the IS have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and available around view monitors.

